Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents

被引：20

作者：

Kamal, A ^{[1
]}

Laxman, N ^{[1
]}

Ramesh, G ^{[1
]}

Srinivas, O ^{[1
]}

Ramulu, P ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00324-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1917 / 1919

页数：3

共 19 条

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