Transcriptional repression by Tup1-Ssn6

被引：117

作者：

Malave, Tania M. ^{[1
]}

Dent, Sharon Y. R. ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2006年 / 84卷 / 04期

关键词：

transcription; repression; Tup1-Ssn6; histone deacetylases and chromatin; corepressor;

D O I：

10.1139/O06-073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Tup1-Ssn6 complex from budding yeast is one of the best studied corepressors and has served as a model for the study of similar corepressor complexes in higher eukaryotes. Tup1-Ssn6 represses multiple subsets of genes when recruited to promoters by sequence-specific DNA binding repressors. Tup1-Ssn6 mediated repression involves interactions among the corepressor and hypoacetylated histones, histone deacetylases, and the RNA transcriptional machinery. Nucleosome positioning is also involved in repression of a subset of Tup1-Ssn6 regulated genes. These findings highlight the importance of chromatin modification states in Tup1-Ssn6 mediated repression. Here we review the multiple mechanisms involved in repression and discuss Tup1-Ssn6 homolog functions in higher organisms. We also present a model for how repression by Tup1-Ssn6 may be established.

引用

页码：437 / 443

页数：7

共 64 条

[1] THE ROX1 REPRESSOR OF THE SACCHAROMYCES-CEREVISIAE HYPOXIC GENES IS A SPECIFIC DNA-BINDING PROTEIN WITH A HIGH-MOBILITY-GROUP MOTIF [J].

BALASUBRAMANIAN, B ;

LOWRY, CV ;

ZITOMER, RS .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (10) :6071-6078

[2] Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation [J].

Bone, JR ;

Roth, SY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (03) :1808-1813

[3] The many HATs of transcription coactivators [J].

Brown, CE ;

Lechner, T ;

Howe, L ;

Workman, JL .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (01) :15-19

[4] Genetics of transcriptional regulation in yeast: Connections to the RNA polymerase II CTD [J].

Carlson, M .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :1-23

[5] Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription [J].

Carrozza, MJ ;

Li, B ;

Florens, L ;

Suganuma, T ;

Swanson, SK ;

Lee, KK ;

Shia, WJ ;

Anderson, S ;

Yates, J ;

Washburn, MP ;

Workman, JL .

CELL, 2005, 123 (04) :581-592

[6] TSF3, A GLOBAL REGULATORY PROTEIN THAT SILENCES TRANSCRIPTION OF YEAST GAL GENES, ALSO MEDIATES REPRESSION BY ALPHA-2 REPRESSOR AND IS IDENTICAL TO SIN4 [J].

CHEN, SM ;

WEST, RW ;

JOHNSON, SL ;

GANS, H ;

KRUGER, B ;

MA, JL .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (02) :831-840

[7]

Courey AJ, 2001, GENE DEV, V15, P2786

[8] Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo [J].

Davie, JK ;

Edmondson, DG ;

Coco, CB ;

Dent, SYR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :50158-50162

[9] Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo [J].

Davie, JK ;

Trumbly, RJ ;

Dent, SYR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (03) :693-703

[10] Histone acetylation at promoters is differentially affected by specific activators and repressors [J].

Deckert, J ;

Struhl, K .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (08) :2726-2735

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