Expedient five-step synthesis of SIB-1508Y from natural nicotine

被引:30
作者
Wagner, Florence F. [1 ]
Comins, Daniel L. [1 ]
机构
[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA
关键词
D O I
10.1021/jo0616052
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.
引用
收藏
页码:8673 / 8675
页数:3
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