Enantioselective reduction of heteroaromatic β,γ-unsaturated ketones as an alternative to allylboration of aldehydes.: Application:: asymmetric synthesis of SIB-1508Y

被引:27
作者
Felpin, FX [1 ]
Bertrand, MJ [1 ]
Lebreton, J [1 ]
机构
[1] Fac Sci & Tech, Synth Organ Lab, CNRS, UMR 6513, F-44322 Nantes 3, France
关键词
allylboration; enantioselective reduction; ketone; SIB-1508Y;
D O I
10.1016/S0040-4020(02)00819-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantioselective reduction of heteroaromatic beta,gamma-unsaturated ketones was found to be an efficient and convenient alternative to the allylboration of corresponding aldehydes. This new method was used for the formal asymmetric synthesis of SIB-1508Y 2. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7381 / 7389
页数:9
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