Endomorphin-1, an endogenous μ-opioid receptor-selective agonist, stimulates oxygen consumption in mice

被引：16

作者：

Asakawa, A

Inui, A ^{[1
]}

Ueno, N

Fujimiya, M

Fujino, MA

Kasuga, M

机构：

[1] Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Shiga Univ Med Sci, Dept Anat, Shiga, Japan

[3] Yamanashi Med Univ, Dept Internal Med 1, Yamanashi, Japan

来源：

HORMONE AND METABOLIC RESEARCH | 2000年 / 32卷 / 02期

关键词：

endomorphin; intracerebroventricular injection; mice; oxygen consumption; mu-opioid receptor;

D O I：

10.1055/s-2007-978587

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was undertaken to investigate the effect of endogenous mu-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol), These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice.

引用

页码：51 / 52

页数：2

共 8 条

[1] Endomorphins have orexigenic and anxiolytic activities in mice [J].