The role of the BAFF/APRIL system on T cell function

被引：146

作者：

Mackay, Fabienne ^{[1
]}

Leung, Helen ^{[1
]}

机构：

[1] Garvan Inst Med Res, Dept Immunol & Inflammat, Darlinghurst, NSW 2010, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

BAFF; BLyS; APRIL; T lymphocytes; autoimmunity; inflammation;

D O I：

10.1016/j.smim.2006.04.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Th1)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：284 / 289

页数：6

共 60 条

[1]

Aderka Dan, 1996, Cytokine and Growth Factor Reviews, V7, P231, DOI 10.1016/S1359-6101(96)00026-3

[2] Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells [J].

Attanavanich, K ;

Kearney, JF .

JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :803-811

[3]

AVERY DT, IN PRESS J CLIN INVE, V112

[4] BAFF mediates survival of peripheral immature B lymphocytes [J].

Batten, M ;

Groom, J ;

Cachero, TG ;

Qian, F ;

Schneider, P ;

Tschopp, J ;

Browning, JL ;

Mackay, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1453-1465

[5] TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma [J].

Batten, M ;

Fletcher, C ;

Ng, LG ;

Groom, J ;

Wheway, J ;

Laâbi, Y ;

Xin, XG ;

Schneider, P ;

Tschopp, J ;

Mackay, CR ;

Mackay, F .

JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :812-822

[6]

BISCHOF D, IN PRESS BLOOD

[7] The molecular architecture of the TNF superfamily [J].

Bodmer, JL ;

Schneider, P ;

Tschopp, J .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (01) :19-26

[8] Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides [J].

Brummel, R ;

Lenert, P .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :2429-2434

[9] Impaired IgA class switching in APRIL-deficient mice [J].

Castigli, E ;

Scott, S ;

Dedeoglu, F ;

Bryce, P ;

Jabara, H ;

Bhan, AK ;

Mizoguchi, E ;

Geha, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (11) :3903-3908

[10] TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo [J].

Diaz-de-Durana, Y ;

Mantchev, GT ;

Bram, RJ ;

Franco, A .

BLOOD, 2006, 107 (02) :594-601

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