Antidepressant principles of the roots of Polygala tenuifolia

被引：46

作者：

Cheng, Mo-Chi

Li, Chia-Ying

Ko, Han-Chieh

Ko, Feng-Nien

Lin, Yun-Lian

Wu, Tian-Shung ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[2] Natl Res Inst Chinese Med, Taipei, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 09期

关键词：

D O I：

10.1021/np060207r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

[I-125] RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B ( 1 and 2) showed significant inhibitory activity, with IC50 values of 30.0 and 6.04 mu M, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

引用

页码：1305 / 1309

页数：5

共 21 条

[1] Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat [J].