Pristionchus pacificus: a well-rounded nematode

被引:99
作者
Hong, Ray L. [1 ]
Sommer, Ralf J. [1 ]
机构
[1] Max Planck Inst Dev Biol, Dept Evolut Biol, D-72076 Tubingen, Germany
关键词
D O I
10.1002/bies.20404
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nematodes pervade Earth's biosphere and occupy innumerable ecological niches. The role of Caenorhabditis elegans as a model for developmental processes has encouraged us to cultivate a second nematode, Pristionchus pacificus, as a comparative counterpoint to address questions in development, behavior and ecology in nematode evolution. We hope that this endeavor, now more than a decade underway, will allow us to project findings onto other comparative models for biological processes. To this end, our laboratory has made an extensive genetic map and mutant screens to understand changes in developmental programs. Recently, we have been capitalizing on the whole genome sequence of P. pacificus to describe more thoroughly the molecular basis for these changes, as well as to better integrate :our molecular knowledge with the biodiversity of Pristionchus species.
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页码:651 / 659
页数:9
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