Autophagy-Mediated Tumor Promotion

被引：453

作者：

Guo, Jessie Yanxiang ^{[1
,2
]}

Xia, Bing ^{[1
,3
]}

White, Eileen ^{[1
,2
]}

机构：

[1] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Radiat Oncol, New Brunswick, NJ 08904 USA

来源：

CELL | 2013年 / 155卷 / 06期

关键词：

SUPPRESSES TUMORIGENESIS; NRF2; INSTABILITY; PROGRESSION; INTERACTS; CANCERS; KEAP1; P53; P62;

D O I：

10.1016/j.cell.2013.11.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.

引用

页码：1216 / 1219

页数：4

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