Learning from oncocytic tumors: Why choose inefficient mitochondria?

被引：92

作者：

Gasparre, Giuseppe ^{[1
,2
]}

Romeo, Giovanni ^{[1
]}

Rugolo, Michela ^{[3
]}

Porcelli, Anna Maria ^{[3
]}

机构：

[1] Univ Bologna, Dip Sci Ginecol Ostetr & Pediat UO Genet Med, Pol Univ S Orsola Malpighi, I-40138 Bologna, Italy

[2] Univ Bari, Dip Biochim & Biol Mol E Quagliariello, I-70100 Bari, Italy

[3] Univ Bologna, Dip Biol Ev Sp, I-40126 Bologna, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2011年 / 1807卷 / 06期

关键词：

Oncocytic tumors; Mitochondria; mtDNA mutations; Complex I; Heteroplasmy; Hypoxia-inducible factor 1-alpha; CYTOCHROME-C-OXIDASE; COMPLEX-I; DNA MUTATIONS; RESPIRATORY-CHAIN; THYROID-TUMORS; RENAL ONCOCYTOMA; COMMON DELETION; OXIDATIVE-PHOSPHORYLATION; PITUITARY-ADENOMAS; MOLECULAR ANALYSIS;

D O I：

10.1016/j.bbabio.2010.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A prominent role for mitochondrial genes and metabolism has been recently characterized in oncocytic transformation of cancer cells. From mitochondrial ultrastructure alterations to respiratory complexes disruption and mutations within mitochondrial genes, oncocytic tumors present with a plethora of features that have helped understand the role that these organelles and their fundamental metabolic functions may play in cancer development. The history of this under-diagnosed subset of tumors and the bioenergetic implications of their mitochondrial derangement are discussed in this review along with the opportunities that oncocytic tumors offer to draw general conclusions on the involvement of mitochondria in cancer. This article is part of a Special Issue entitled: Bioenergetics of Cancer. (C) 2010 Elsevier B.V. All rights reserved.

引用

收藏

页码：633 / 642

页数：10

相关论文

共 99 条

[1] CHROMOSOMAL LOCALIZATION OF THE HUMAN GENE ENCODING THE 51-KDA SUBUNIT OF MITOCHONDRIAL COMPLEX-I (NDUFV1) TO 11Q13 [J].

ALI, ST ;

DUNCAN, AMV ;

SCHAPPERT, K ;

HENG, HHQ ;

TSUI, LC ;

CHOW, W ;

ROBINSON, BH .

GENOMICS, 1993, 18 (02) :435-439

[2] Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy [J].

Ambrosini-Spaltro, A ;

Salvi, F ;

Betts, CM ;

Frezza, GP ;

Piemontese, A ;

Del Prete, P ;

Baldoni, C ;

Foschini, MP ;

Viale, G .

VIRCHOWS ARCHIV, 2006, 448 (04) :442-448

[3] Scanning electron microscopy of the interior of cells in Hurthle cell tumors [J].

Ambu, R ;

Riva, A ;

Lai, ML ;

Loffredo, F ;

Riva, FT ;

Tandler, B .

ULTRASTRUCTURAL PATHOLOGY, 2000, 24 (04) :211-219

[4] Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling [J].

Baba, Masaya ;

Hong, Seung-Beom ;

Sharma, Nirmala ;

Warren, Michelle B. ;

Nickerson, Michael L. ;

Iwamatsu, Akihiro ;

Esposito, Dominic ;

Gillette, William K. ;

Hopkins, Ralph F., III ;

Hartley, James L. ;

Furihata, Mutsuo ;

Oishi, Shinya ;

Zhen, Wei ;

Burke, Terrence R., Jr. ;

Linehan, W. Marston ;

Schmidt, Laura S. ;

Zbar, Berton .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) :15552-15557

[5] Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors [J].

Baris, O ;

Savagner, F ;

Nasser, V ;

Loriod, B ;

Granjeaud, S ;

Guyetant, S ;

Franc, B ;

Rodien, P ;

Rohmer, V ;

Bertucci, F ;

Birnbaum, D ;

Malthièry, Y ;

Reynier, P ;

Houlgatte, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :994-1005

[6] HEREDITARY MULTIPLE FIBROFOLLICULOMAS WITH TRICHODISCOMAS AND ACROCHORDONS [J].

BIRT, AR ;

HOGG, GR ;

DUBE, WJ .

ARCHIVES OF DERMATOLOGY, 1977, 113 (12) :1674-1677

[7] Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas [J].

Bonora, E. ;

Evangelisti, C. ;

Bonichon, F. ;

Tallini, G. ;

Romeo, G. .

BRITISH JOURNAL OF CANCER, 2006, 95 (11) :1529-1536

[8] Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III [J].

Bonora, Elena ;

Porcelli, Anna Maria ;

Gasparre, Giuseppe ;

Biondi, Annalisa ;

Ghelli, Anna ;

Carelli, Valerio ;

Baracca, Alessandra ;

Tallini, Giovanni ;

Martinuzzi, Andrea ;

Lenaz, Giorgio ;

Rugolo, Michela ;

Romeo, Giovanni .

CANCER RESEARCH, 2006, 66 (12) :6087-6096

[9] Prolyl hydroxylases as regulators of cell metabolism [J].

Boulahbel, Houda ;

Duran, Raul V. ;

Gottlieb, Eyal .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 :291-294

[10] Energy converting NADH:Quinone oxidoreductase (Complex I) [J].

Brandt, Ulrich .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :69-92

← 1 2 3 4 5 6 7 8 9 10 →