Learning from oncocytic tumors: Why choose inefficient mitochondria?

被引：92

作者：

Gasparre, Giuseppe ^{[1
,2
]}

Romeo, Giovanni ^{[1
]}

Rugolo, Michela ^{[3
]}

Porcelli, Anna Maria ^{[3
]}

机构：

[1] Univ Bologna, Dip Sci Ginecol Ostetr & Pediat UO Genet Med, Pol Univ S Orsola Malpighi, I-40138 Bologna, Italy

[2] Univ Bari, Dip Biochim & Biol Mol E Quagliariello, I-70100 Bari, Italy

[3] Univ Bologna, Dip Biol Ev Sp, I-40126 Bologna, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2011年 / 1807卷 / 06期

关键词：

Oncocytic tumors; Mitochondria; mtDNA mutations; Complex I; Heteroplasmy; Hypoxia-inducible factor 1-alpha; CYTOCHROME-C-OXIDASE; COMPLEX-I; DNA MUTATIONS; RESPIRATORY-CHAIN; THYROID-TUMORS; RENAL ONCOCYTOMA; COMMON DELETION; OXIDATIVE-PHOSPHORYLATION; PITUITARY-ADENOMAS; MOLECULAR ANALYSIS;

D O I：

10.1016/j.bbabio.2010.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A prominent role for mitochondrial genes and metabolism has been recently characterized in oncocytic transformation of cancer cells. From mitochondrial ultrastructure alterations to respiratory complexes disruption and mutations within mitochondrial genes, oncocytic tumors present with a plethora of features that have helped understand the role that these organelles and their fundamental metabolic functions may play in cancer development. The history of this under-diagnosed subset of tumors and the bioenergetic implications of their mitochondrial derangement are discussed in this review along with the opportunities that oncocytic tumors offer to draw general conclusions on the involvement of mitochondria in cancer. This article is part of a Special Issue entitled: Bioenergetics of Cancer. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：633 / 642

页数：10

共 99 条

[61]

Müller-Höcker J, 1998, ULTRASTRUCT PATHOL, V22, P91

[62] Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction [J].

MullerHocker, J ;

Aust, D ;

Napiwotzky, J ;

Munscher, C ;

Link, TA ;

Seibel, P ;

Schneeweiss, SG ;

Kadenbach, B .

HUMAN PATHOLOGY, 1996, 27 (06) :532-541

[63]

MULLERHOCKER J, 1992, PATHOL RES PRACT, V188, P701

[64] The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I [J].

Murai, Masatoshi ;

Ishihara, Atsushi ;

Nishioka, Takaaki ;

Yagi, Takao ;

Miyoshi, Hideto .

BIOCHEMISTRY, 2007, 46 (21) :6409-6416

[65] Involvement of the chromosomal region 11q13 in renal oncocytoma: Case report and literature review [J].

Neuhaus, C ;

Dijkhuizen, T ;

vandenBerg, E ;

Storkel, S ;

Stockle, M ;

Mensch, B ;

Huber, C ;

Decker, HJ .

CANCER GENETICS AND CYTOGENETICS, 1997, 94 (02) :95-98

[66] Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome [J].

Nickerson, ML ;

Warren, MB ;

Toro, JR ;

Matrosova, V ;

Glenn, G ;

Turner, ML ;

Duray, P ;

Merino, M ;

Choyke, P ;

Pavlovich, CP ;

Sharma, N ;

Walther, M ;

Munroe, D ;

Hill, R ;

Maher, E ;

Greenberg, C ;

Lerman, MI ;

Linehan, WM ;

Zbar, B ;

Schmidt, LS .

CANCER CELL, 2002, 2 (02) :157-164

[67] Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide [J].

Nisoli, E ;

Clementi, E ;

Paolucci, C ;

Cozzi, V ;

Tonello, C ;

Sciorati, C ;

Bracale, R ;

Valerio, A ;

Francolini, M ;

Moncada, S ;

Carruba, MO .

SCIENCE, 2003, 299 (5608) :896-899

[68] Nitric oxide and mitochondrial biogenesis [J].

Nisoli, Enzo ;

Carruba, Michele O. .

JOURNAL OF CELL SCIENCE, 2006, 119 (14) :2855-2862

[69]

Niveiro M, 2004, ARCH PATHOL LAB MED, V128, P776

[70]

OSTERGAARD J, 2009, ACTA OPHTHALMOL

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