Enantiomeric separation of three chiral drugs by nonaqueous capillary electrophoresis with triethylamine as additive

被引：13

作者：

Ren, XQ

Huang, AJ

Wang, TS

Sun, YL ^{[1
]}

Sun, ZP

机构：

[1] Peking Univ, Dept Chem, Beijing 100871, Peoples R China

[2] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China

来源：

CHROMATOGRAPHIA | 1999年 / 50卷 / 9-10期

关键词：

capillary electrophoresis; enantioseparation; non-aqueous media; triethylamine;

D O I：

10.1007/BF02493671

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric separation of chiral drugs by capillary electrophoresis (CE) in nonaqueous system has been investigated. Successful separation of bepridil, ondansetron and pinacidil in formamide using beta-cyclodextrin as chiral selector were achieved. The addition of triethylamine into the background electrolyte enhanced the enantiomeric discrimination.

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收藏

页码：625 / 628

页数：4

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