Total synthesis of (+)-4-deoxygigantecin

被引:25
作者
Makabe, H
Tanaka, A
Oritani, T
机构
[1] TOHOKU UNIV,FAC AGR,DEPT APPL BIOL CHEM,GRAD SCH AGR,AOBA KU,SENDAI,MIYAGI 981,JAPAN
[2] TOHOKU UNIV,FAC AGR,DIV ENVIRONM BIOREMEDIAT,GRAD SCH AGR,AOBA KU,SENDAI,MIYAGI 981,JAPAN
关键词
D O I
10.1016/S0040-4039(97)00856-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(+)-4-Deoxygigantecin (1) was totally synthesized from enantiomerically pure (-)-muricatacin (3). Thus, 3 afforded the key intermediate 5 through a five-step reaction sequence, which was then converted to (+)-4-deoxygigantecin (1) via the formation of bis-tetrahydrofuran unit 1 1 and a coupling reaction with iodo lactone synthon 1 6. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:4247 / 4250
页数:4
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