Total synthesis of (+)-4-deoxygigantecin

被引：25

作者：

Makabe, H

Tanaka, A

Oritani, T

机构：

[1] TOHOKU UNIV,FAC AGR,DEPT APPL BIOL CHEM,GRAD SCH AGR,AOBA KU,SENDAI,MIYAGI 981,JAPAN

[2] TOHOKU UNIV,FAC AGR,DIV ENVIRONM BIOREMEDIAT,GRAD SCH AGR,AOBA KU,SENDAI,MIYAGI 981,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(97)00856-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-4-Deoxygigantecin (1) was totally synthesized from enantiomerically pure (-)-muricatacin (3). Thus, 3 afforded the key intermediate 5 through a five-step reaction sequence, which was then converted to (+)-4-deoxygigantecin (1) via the formation of bis-tetrahydrofuran unit 1 1 and a coupling reaction with iodo lactone synthon 1 6. (C) 1997 Elsevier Science Ltd.

引用

页码：4247 / 4250

页数：4

共 23 条

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