Matrix metalloproteinases: multifunctional contributors to tumor progression

被引：541

作者：

McCawley, LJ ^{[1
]}

Matrisian, LM ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell Biol, Nashville, TN 37232 USA

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1357-4310(00)01686-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases. Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs were originally implicated in invasion and metastasis during cancer progression. However, recent work extends a role for MMPs during multiple stages of tumor progression to include other functions such as growth, angiogenesis and migration. Based on studies in animal models implicating MMP activity in cancer, synthetic MMP inhibitors are currently being tested in a clinical setting.

引用

页码：149 / 156

页数：8

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