Inhibitory effects of baeomycesic acid from the lichen Thamnolia subuliformis on 5-lipoxygenase in vitro

被引：20

作者：

Ingolfsdottir, K

Wiedemann, B

Birgisdottir, M

Nenninger, A

Jonsdottir, S

Wagner, H

机构：

[1] UNIV MUNICH,INST PHARMAZEUT BIOL,MUNICH,GERMANY

[2] UNIV ICELAND,INST SCI,IS-107 REYKJAVIK,ICELAND

来源：

PHYTOMEDICINE | 1997年 / 4卷 / 02期

关键词：

Thamnolia subuliformis; lichen; baeomycesic acid; 5-lipoxygenase; arachidonate metabolism;

D O I：

10.1016/S0944-7113(97)80056-6

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Baeomycesic acid (1), a beta-orcinol depside isolated from the lichen Thamnolia subuliformis (Ehrh.) W. Culb. was tested for in vitro inhibitory effects on arachidonate metabolism. Results showed that baeomycesic acid has potent dose-dependent inhibitory effects on 5-lipoxygenase isolated from porcine leucocytes, with an IC50 value of 8.3 mu M. Structure-activity relationships are discussed in comparison to other phenolic lichen constituents. Baeomycesic was inactive when tested for in vitro inhibitory effects against cyclooxygenase isolated from sheep seminal vesicle microsomes.

引用

页码：125 / 128

页数：4

共 14 条

[1] Cyclooxygenase and lipoxygenase inhibitors in cancer therapy [J].