Antenatal diagnosis and treatment of fetal hypothyroidism - A report of two cases

被引:24
作者
Bruner, JP
Dellinger, EH
机构
[1] Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Vanderbilt University Medical Center, Nashville, TN
关键词
fetal goiter; Graves' disease; cordocentesis;
D O I
10.1159/000264468
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Fetal goiter in the presence of maternal Graves' disease can signify either hyperthyroidism or hypothyroidism in the fetus. Two patients with Graves' disease taking propylthiouracil were found to have a fetal goiter on a prenatal sonogram. Fetal blood sampling identified hypothyroidism in both instances. Administration of intraamniotic thyroxine resulted in rapid resolution of the goiter, normalization of subsequent fetal thyroid studies, and delivery of a euthyroid fetus. Cordocentesis allows accurate diagnosis and follow-up of fetal thyroid dysfunction and prompt initiation of appropriate therapy.
引用
收藏
页码:200 / 204
页数:5
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