Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of Huang-Lian-Jie-Du-Tang decoction

被引：30

作者：

Ma, Zhao-Tang ^{[1
]}

Yang, Xiu-Wei ^{[1
]}

Zhang, Ying ^{[2
]}

Liu, Jian-Xun ^{[2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Dept Nat Med,Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] China Acad Chinese Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 05期

基金：

国家高技术研究发展计划(863计划);

关键词：

pharmacokinetics; alkaloid; flavonoid; Scutellaria baicalensis; Huang-Lian-Jie-Du-Tang decoction; Coptis chinensis; TRANSIENT CEREBRAL-ISCHEMIA; OREN-GEDOKU-TO; MASS-SPECTROMETRY; COPTIDIS RHIZOMA; RATS; BERBERINE;

D O I：

10.1080/10286020.2014.913577

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Pharmacochemistry and integrated pharmacokinetics of six alkaloids (groenlandicine, berberine, palmatine, epiberberine, jatrorrhizine, and columbamine) after oral administration of Huang-Lian-Jie-Du-Tang (HLJDT) decoction were investigated in this paper. The method of plasma pharmacochemistry was applied to predict the potential bioactive components in HLJDT decoction. Based on the accurate molecular weight, 10 components including 2 flavonoids (baicalin and wogonoside), 1 iridoid glycoside (geniposide), and 7 alkaloids (above-mentioned 6 alkaloids and coptisine) were structurally identified. Then, integrated pharmacokinetics of the alkaloids in Sprague-Dawley rats after oral administration of HLJDT decoction was investigated by HPLC method. The results showed that the pharmacokinetic behaviors of the alkaloids were different although their chemical structures were similar. This study developed a method to predict the potential bioactive components in HLJDT decoction and research the pharmacokinetic behaviors of the potential bioactive components.

引用

页码：483 / 496

页数：14

共 24 条

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