Optimization of headspace solid-phase microextraction by means of an experimental design for the determination of methyl tert.-butyl ether in water by gas chromatography-flame ionization detection

被引:51
作者
Dron, J [1 ]
Garcia, R [1 ]
Millán, E [1 ]
机构
[1] Univ Basque Country, Fac Quim, Dept Quim Aplicada, San Sebastian 20080, Spain
关键词
headspace analysis; solid-phase microextraction; experimental design; water analysis; methyl tert.-butyl ether;
D O I
10.1016/S0021-9673(02)00359-X
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A procedure for determination of methyl tert.-butyl ether (MTBE) in water by headspace solid-phase microextraction (HS-SPME) has been developed. The analysis was carried out by gas chromatography with flame ionization detection. The extraction procedure, using a 65-mum poly(dimethylsiloxane)-divinylbenzene SPME fiber, was optimized following experimental design. A fractional factorial design for screening and a central composite design for optimizing the significant variables were applied. Extraction temperature and sodium chloride concentration were significant variables, and 20 degreesC and 300 g/l were, respectively chosen for the best extraction response. With these conditions, an extraction time of 5 min was sufficient to extract MTBE. The calibration linear range for MTBE was 5-500 mug/l and the detection limit 0.45 mug/l. The relative standard deviation, for seven replicates of 250 mug/l MTBE in water, was 6.3%. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:259 / 264
页数:6
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