The causes and consequences of genetic variation in dengue virus

被引：146

作者：

Holmes, EC ^{[1
]}

Burch, SS ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0966-842X(99)01669-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in virulence, suggests that in the future we might be exposed to viruses with an expanded range of pathogenic properties.

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收藏

页码：74 / 77

页数：4

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