A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

被引：117

作者：

Jiang, Jiacheng ^{[1
]}

Tian, Xiaohe ^{[2
]}

Xu, Changzhi ^{[3
]}

Wang, Shuxin ^{[1
]}

Feng, Yan ^{[1
]}

Chen, Man ^{[1
]}

Yu, Haizhu ^{[1
]}

Zhua, Manzhou ^{[1
]}

Meng, Xiangming ^{[1
]}

机构：

[1] Anhui Univ, Dept Chem, Hefei 230601, Anhui, Peoples R China

[2] Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China

[3] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 26期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-MICROSCOPY; CANCER; VISCOSITY; CELLS; DYE;

D O I：

10.1039/c7cc00752c

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process of autophagy. The Lyso-OC probe exhibited desirable optical properties and a detection signal that was selective to the polarity change. More importantly, Lyso-OC displayed real-time monitoring of autophagy in living cells.

引用

页码：3645 / 3648

页数：4

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