学术探索
学术期刊
新闻热点
数据分析
智能评审

Tachykinin-induced changes in beta-endorphin gene expression in the rat arcuate nucleus

被引：8
作者：
Magoul, R
Tramu, G
机构：
[1] URA CNRS 339,NEUROCYTOCHIM FONCT LAB,F-33405 TALENCE,FRANCE
[2] UNIV SIDI MOHAMMED BEN ABDELLAH,FAC SCI,PHYSIOL ANIM LAB,FES,MOROCCO
来源：
NEUROSCIENCE LETTERS | 1997年 / 223卷 / 02期
关键词：
tachykinins; proopiomelanocortin; beta-endorphin; arcuate nucleus; in situ hybridization; gene expression;
D O I：
10.1016/S0304-3940(97)13407-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous neuroanatomical data have indicated the presence of synaptic connections between tachykinergic terminals and proopiomelanocortin (POMC) neurons in the arcuate nucleus. Consequently, tachykinins may regulate the activity of POMC neurons. To evaluate the functional signification of this regulation, the effect of intracerebroventricular injections of neurokinin A (NKA) on POMC mRNA levels was studied by using in situ hybridization. Repeated injection of NKA (40 mu g/animal per day during 3 days) induced a 48% increase in POMC mRNA expression as compared to NaCl injected control animals. In conclusion the results of this study show an excitatory effect of tachykinin on POMC neurons and suggest a direct and/or indirect excitatory control of POMC neuronal activity by endogenous tachykinins. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：93 / 96
页数：4
相关论文
共 29 条
[1]   ESTROGEN CONCENTRATION BY SUBSTANCE P-IMMUNOREACTIVE NEURONS IN THE MEDIAL BASAL HYPOTHALAMUS OF THE FEMALE RAT [J].
AKESSON, TR ;
MICEVYCH, PE .
JOURNAL OF NEUROSCIENCE RESEARCH, 1988, 19 (04) :412-&
[2]  
AUTELITANO DJ, 1989, ANNU REV PHYSIOL, V51, P715, DOI 10.1146/annurev.physiol.51.1.715
[3]   GLUCOCORTICOID REGULATION OF PROOPIOMELANOCORTIN MESSENGER RIBONUCLEIC-ACID CONTENT OF RAT HYPOTHALAMUS [J].
BEAULIEU, S ;
GAGNE, B ;
BARDEN, N .
MOLECULAR ENDOCRINOLOGY, 1988, 2 (08) :727-731
[4]   SHORT-TERM STARVATION DECREASES POMC MESSENGER-RNA BUT DOES NOT ALTER GNRH MESSENGER-RNA IN THE BRAIN OF ADULT MALE-RATS [J].
BERGENDAHL, M ;
WIEMANN, JN ;
CLIFTON, DK ;
HUHTANIEMI, I ;
STEINER, RA .
NEUROENDOCRINOLOGY, 1992, 56 (06) :913-920
[5]   GONADAL-STEROID REGULATION OF SUBSTANCE-P (SP) AND SP-ENCODING MESSENGER RIBONUCLEIC-ACIDS IN THE RAT ANTERIOR-PITUITARY AND HYPOTHALAMUS [J].
BROWN, ER ;
HARLAN, RE ;
KRAUSE, JE .
ENDOCRINOLOGY, 1990, 126 (01) :330-340
[6]   TESTOSTERONE REGULATION OF PROOPIOMELANOCORTIN MESSENGER RIBONUCLEIC-ACID IN THE ARCUATE NUCLEUS OF THE MALE-RAT [J].
CHOWENBREED, J ;
FRASER, HM ;
VICIAN, L ;
DAMASSA, DA ;
CLIFTON, DK ;
STEINER, RA .
ENDOCRINOLOGY, 1989, 124 (04) :1697-1702
[7]  
CIVELLI O, 1982, J BIOL CHEM, V257, P6783
[8]   OPIOID REGULATION OF PROOPIOMELANOCORTIN (POMC) GENE-EXPRESSION IN THE RAT-BRAIN AS STUDIED BY IN-SITU HYBRIDIZATION [J].
DEYEBENES, EG ;
PELLETIER, G .
NEUROPEPTIDES, 1993, 25 (02) :91-94
[9]   OPPOSITE REGULATION OF PRO-OPIOMELANOCORTIN GENE-TRANSCRIPTION BY GLUCOCORTICOIDS AND CRH [J].
GAGNER, JP ;
DROUIN, J .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1985, 40 (01) :25-32
[10]   EFFECTS OF VARIOUS TACHYKININS ON PITUITARY LH-SECRETION, FEEDING, AND SEXUAL-BEHAVIOR IN THE RAT [J].
KALRA, SP ;
SAHU, A ;
DUBE, MG ;
KALRA, PS .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 632 :332-338
123