Unwinding a path to nuclear β-catenin

被引：34

作者：

He, Xi ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Program Neurobiol, Boston, MA 02115 USA

来源：

CELL | 2006年 / 127卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.09.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, Yang et al. (2006b) show that PDGF, a growth factor that induces the transition of epithelial cells to mesenchymal cells, stimulates the c-Abl kinase-dependent phosphorylation of p68 RNA helicase. Phosphorylated p68 dissociates beta-catenin from the Axin destruction complex, thereby promoting nuclear beta-catenin signaling independent of Wnt activation.

引用

页码：40 / 42

页数：3

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