Source memory and frontal functioning in Parkinson's disease

被引:35
作者
Drag, Lauren L. [1 ]
Bieliauskas, Linas A.
Kaszniak, Alfred W. [3 ]
Bohnen, Nicolaas I. [2 ]
Glisky, Elizabeth L. [3 ]
机构
[1] Univ Michigan, Dept Psychiat, Div Neuropsychol, Ann Arbor, MI 48105 USA
[2] Univ Michigan, Dept Neurol, Ann Arbor, MI 48105 USA
[3] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
关键词
Dopamine; Cognition; Frontal lobe; Neuropsychology; Medication; Executive functioning; SPATIAL WORKING-MEMORY; COGNITIVE DEFICITS; DOPAMINERGIC MODULATION; BASAL GANGLIA; IMPAIRMENT; SYSTEM; AGE; CRYPTOMNESIA; ASSOCIATION; CIRCUITS;
D O I
10.1017/S1355617709090572
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
The most extensively described pathological abnormality in Parkinson's disease (PD) is loss of dopaminergic neurons in the substantia nigra pars compacta and the ventral tegmental area, with degeneration of their striatal terminals. Because of the intimate connections between the striatum and the frontal lobes, individuals with PD often demonstrate impairments oil those tasks relying on the prefrontal cortex (e.g., tests of executive functioning). Source memory, or memory for context, is believed to rely oil the prefrontal cortex and has been previously associated with executive functioning performance, although it has received little attention in the PD literature. Executive functioning and source memory were measured in a group of nondemented PD patients and healthy control participants. Within the PD group an anti-Parkinson's medication withdrawal Manipulation was used to examine whether Source memory was affected by phasic changes in dopamine levels. Compared to healthy control participants, PD patients were impaired ill Source memory (both on- and off-medication) and on a composite measure of executive functioning. Within the PD group, medication administration improved motor performance but did not have a significant effect On Source memory. (JINS, 2009 15,399-406.)
引用
收藏
页码:399 / 406
页数:8
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