Piccolo, a presynaptic zinc finger protein structurally related to bassoon

被引：221

作者：

Fenster, SD

Chung, WJ

Zhai, R

Cases-Langhoff, C

Voss, B

Garner, AM

Kaempf, U

Kindler, S

Gundelfinger, ED

Garner, CC ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL 35294 USA

[2] Univ Hamburg, Ctr Mol Neurobiol, D-20246 Hamburg, Germany

[3] Univ Hamburg, Inst Cellular Biochem & Clin Neurobiol, D-20246 Hamburg, Germany

[4] Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany

来源：

NEURON | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(00)80883-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Analysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins were found to be shared components of glutamatergic and GABAergic CNS synapses but not of the cholinergic neuromuscular junction. The Piccolo zinc fingers were found to interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA1. We show that PRA1 is a synaptic vesicle-associated protein that is colocalized with Piccolo in nerve terminals of hippocampal primary neurons. These data suggest that Piccolo plays a role in the trafficking of synaptic vesicles (SVs) at the active zone.

引用

页码：203 / 214

页数：12