Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers

Solution phase parallel synthesis of equimolar mixtures of ureas was accomplished using a solid-supported ''covalent scavenger'' (aminomethylpolystyrene) to remove isocyanate impurities. Screening of these purified mixtures for antirhinoviral activity in a whole cell assay and subsequent deconvolution of hit mixtures afforded novel antirhinoviral agents with low cytotoxicities. Copyright (C) 1996 Elsevier Science Ltd