Traceless solid-phase organic synthesis

被引:146
作者
Blaney, P [1 ]
Grigg, R [1 ]
Sridharan, V [1 ]
机构
[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England
关键词
D O I
10.1021/cr0103827
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An overview is given on the solid-phase synthesis of traceless organic compounds. Focus is on (a) traceless linkers, (b) miscellaneous traceless linkers, (c) cyclization-cleavage strategies in traceless synthesis, (d) traceless linkers for tertiary amine synthesis, and (e) traceless linkers for ureas, secondary amides, sulfonides, carbamates, and gaunidines.
引用
收藏
页码:2607 / 2624
页数:18
相关论文
共 150 条
  • [1] Solid phase synthesis of sulfahydantoins
    Albericio, F
    Garcia, J
    Michelotti, EL
    Nicolás, E
    Tice, CM
    [J]. TETRAHEDRON LETTERS, 2000, 41 (17) : 3161 - 3163
  • [2] [Anonymous], COMPREHENSIVE MED CH
  • [3] Activation method to prepare a highly reactive acylsulfonamide ''safety-catch'' linker for solid-phase synthesis
    Backes, BJ
    Virgilio, AA
    Ellman, JA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (12) : 3055 - 3056
  • [4] CARBON-CARBON BOND-FORMING METHODS ON SOLID SUPPORT - UTILIZATION OF KENNER SAFETY-CATCH LINKER
    BACKES, BJ
    ELLMAN, JA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (24) : 11171 - 11172
  • [5] AN ASYMMETRIC ROUTE TO THE DEMETHOXY-FUMITREMORGINS
    BAILEY, PD
    HOLLINSHEAD, SP
    MCLAY, NR
    EVERETT, JH
    REYNOLDS, CD
    WOOD, SD
    GIORDANO, F
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (04): : 451 - 458
  • [6] RULES FOR RING-CLOSURE
    BALDWIN, JE
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (18) : 734 - 736
  • [7] Bannwarth W., 2000, COMBINATORIAL CHEM
  • [8] Solid-phase synthesis of cyclic imides
    Barn, DR
    Morphy, JR
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (02): : 151 - 156
  • [9] A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation
    Berst, F
    Holmes, AB
    Ladlow, M
    Murray, PJ
    [J]. TETRAHEDRON LETTERS, 2000, 41 (34) : 6649 - 6653
  • [10] Bhandari A, 1999, SYNTHESIS-STUTTGART, P1951