Revised structure of a homonojirimycin isomer from Aglaonema treubii:: First example of a naturally occurring α-homoallonojirimycin

被引：19

作者：

Martin, OR

Compain, P

Kizu, H

Asano, N

机构：

[1] Inst Chim Organ & Analyt, Fac Sci, F-45067 Orleans 2, France

[2] Hokuriku Univ, Fac Pharmaceut Sci, Kanagawa 92011, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00551-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure of a homonojirimycin isomer isolated from Aglaonema treublii and originally proposed as alpha-3,3-di-epi-homonojirimycin was revised to alpha-4-epi-homonojirimycin 3 ("alpha-homoallonojirimycin") on the basis of NMR analysis and synthetic studies. Its activity as a glycosidase inhibitor is compared to that of other homonojirimycin isomers. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3171 / 3174

页数：4

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