Gout tophus detection-A comparison of dual-energy CT (DECT) and histology

被引：101

作者：

Melzer, Ralph ^{[1
]}

Pauli, Chantal ^{[2
]}

Treumann, Thomas ^{[3
]}

Krauss, Bernhard ^{[4
]}

机构：

[1] Luzerner Kantonsspital, Clin Rheumatol, CH-6000 Luzern 16, Switzerland

[2] Luzerner Kantonsspital, Inst Pathol, CH-6000 Luzern 16, Switzerland

[3] Luzerner Kantonsspital, Inst Radiol, CH-6000 Luzern 16, Switzerland

[4] Siemens AG, Healthcare Sect, Imaging & Therapy Div, Forchheim, Germany

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 2014年 / 43卷 / 05期

关键词：

Dual-energy computed tomography; DECT; Gout; Tophi; Histology; COMPUTED-TOMOGRAPHY; URATE DEPOSITS; MANAGEMENT;

D O I：

10.1016/j.semarthrit.2013.11.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives: To compare dual-energy CT images (DECT) directly with gold standard histology. Methods: A 85-year-old woman with chronic recurrent gouty arthritis and macroscopically visible tophi was assessed with DECT-scans of her feet. When she died 7 days later, three tophi in different regions and in different tissues of her left foot were processed for histological examination. Results: Of the selected tophi, two were almost completely missed by the color-coding DECT sequences. The tophi remained in most of their volume below the detection threshold value of 150 HU (default value). Conclusions: It could be demonstrated that DECT only highlights the dense tophi (corresponding of approximately 15-20 vol% urate in the tophus). Less dense tophi, despite considerable size, will be missed in the color-coded images. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：662 / 665

页数：4

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