Orchestrating ontogenesis: variations on a theme by sonic hedgehog

被引:208
作者
Ingham, Philip W.
Placzek, Marysia
机构
[1] Inst Mol & Cell Biol, Singapore 138673, Singapore
[2] Univ Sheffield, MRC, Ctr Dev Dev & Biomed Genet, Sheffield S10 2TN, S Yorkshire, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/nrg1969
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Embryonic development is an emergent process in which increasing complexity is generated by sequential cellular interactions. Recently, it has become clear that such interactions are mediated by just a few families of signalling molecules; but how does this limited repertoire elicit the diversity of form that is characteristic of multicellular organisms? Here we review the various ways in which a member of one such family, the sonic hedgehog (SHH) protein, is deployed during embryonic development. These examples of SHH function provide paradigms for inductive interactions that should help to inform attempts to recapitulate cellular programming and organogenesis in vitro.
引用
收藏
页码:841 / 850
页数:10
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