Orchestrating ontogenesis: variations on a theme by sonic hedgehog

被引：208

作者：

Ingham, Philip W.

Placzek, Marysia

机构：

[1] Inst Mol & Cell Biol, Singapore 138673, Singapore

[2] Univ Sheffield, MRC, Ctr Dev Dev & Biomed Genet, Sheffield S10 2TN, S Yorkshire, England

来源：

NATURE REVIEWS GENETICS | 2006年 / 7卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrg1969

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Embryonic development is an emergent process in which increasing complexity is generated by sequential cellular interactions. Recently, it has become clear that such interactions are mediated by just a few families of signalling molecules; but how does this limited repertoire elicit the diversity of form that is characteristic of multicellular organisms? Here we review the various ways in which a member of one such family, the sonic hedgehog (SHH) protein, is deployed during embryonic development. These examples of SHH function provide paradigms for inductive interactions that should help to inform attempts to recapitulate cellular programming and organogenesis in vitro.

引用

页码：841 / 850

页数：10

共 94 条

[31] The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog [J].