P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders

被引：45

作者：

Carlson, SR ^{[1
]}

Iacono, WG ^{[1
]}

McGue, M ^{[1
]}

机构：

[1] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA

来源：

BIOLOGICAL PSYCHOLOGY | 2002年 / 61卷 / 1-2期

关键词：

P300; amplitude; alcohol abuse/dependence; discordant twins; biological markers; endophenotype;

D O I：

10.1016/S0301-0511(02)00059-5

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The sons of alcoholics have repeatedly been found to have reduced P300 amplitude. Further, quantitative behavioral genetic and molecular genetic studies indicating a genetic influence on P300 amplitude have fueled speculation that this component may be a biological vulnerability marker for alcoholism. To further explore this possibility, we examined P300 in adolescent twin pairs from an epidemiological sample who were (a) discordant for alcohol abuse/dependence, (b) concordant for alcohol abuse/dependence, or (c) concordant for the absence of alcohol abuse/dependence and other relevant disorders. For discordant pairs, the alcohol abusing/dependent twins' amplitude did not differ from that of non-alcoholic co-twins. Pairs free of psychopathology had greater amplitudes than both alcoholism discordant and concordant pairs. P300 amplitude was more similar in monozygotic than dizygotic discordant pairs, suggesting a genetic influence on P300 amplitude in this group. The findings are consistent with P300 amplitude being a marker of vulnerability to alcohol use disorders. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：203 / 227

页数：25

共 83 条

[21] P300 IN MAJOR DEPRESSIVE DISORDER [J].

DINER, BC ;

HOLCOMB, PJ ;

DYKMAN, RA .

PSYCHIATRY RESEARCH, 1985, 15 (03) :175-184

[22]

Fabiani M., 2000, Handbook of Psychophysiology, V2, P53

[23] Poling behaviour at the grain boundaries of ferroelectric PZT thin films investigated by Electric Scanning Force Microscopy [J].

Franke, K ;

Huelz, H ;

Seifert, S .

FERROELECTRICS LETTERS SECTION, 1997, 23 (1-2) :1-6

[24] EVENT-RELATED POTENTIALS (ERPS) AS INDICATORS OF RISK FOR SCHIZOPHRENIA [J].

FRIEDMAN, D ;

SQUIRESWHEELER, E .

SCHIZOPHRENIA BULLETIN, 1994, 20 (01) :63-74

[25] A NEW METHOD FOR OFF-LINE REMOVAL OF OCULAR ARTIFACT [J].

GRATTON, G ;

COLES, MGH ;

DONCHIN, E .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1983, 55 (04) :468-484

[26] HERITABILITY OF SUBSTANCE ABUSE AND ANTISOCIAL-BEHAVIOR - A STUDY OF MONOZYGOTIC TWINS REARED APART [J].

GROVE, WM ;

ECKERT, ED ;

HESTON, L ;

BOUCHARD, TJ ;

SEGAL, N ;

LYKKEN, DT .

BIOLOGICAL PSYCHIATRY, 1990, 27 (12) :1293-1304

[27] Absence of visual and auditory P300 reduction in nondepressed male and female alcoholics [J].

Hill, SY ;

Locke, J ;

Steinhauer, SR .

BIOLOGICAL PSYCHIATRY, 1999, 46 (07) :982-989

[28] P300 AMPLITUDE DECREMENTS IN CHILDREN FROM FAMILIES OF ALCOHOLIC FEMALE PROBANDS [J].

HILL, SY ;

MUKA, D ;

STEINHAUER, S ;

LOCKE, J .

BIOLOGICAL PSYCHIATRY, 1995, 38 (09) :622-632

[29] EVENT-RELATED POTENTIALS AS MARKERS FOR ALCOHOLISM RISK IN HIGH-DENSITY FAMILIES [J].

HILL, SY ;

STEINHAUER, SR ;

ZUBIN, J ;

BAUGHMAN, T .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (04) :545-554

[30] Factors predicting the onset of adolescent drinking in families at high risk for developing alcoholism [J].

Hill, SY ;

Shen, S ;

Lowers, L ;

Locke, J .

BIOLOGICAL PSYCHIATRY, 2000, 48 (04) :265-275

← 1 2 3 4 5 6 7 8 9 →