Potent tyrosinase inhibitors from Trifolium balansae

被引：33

作者：

Sabudak, Temine

Khan, Mahmut Tareq Hassan

Choudhary, M. Iqbal

Oksuz, Sevil ^{[1
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Chem, TR-34116 Istanbul, Turkey

[2] Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan

[3] Trakya Univ, Sci & Art Fac, Dept Chem, Edirne, Turkey

[4] Univ Karachi, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 07期

关键词：

Trifolium balansae; Leguminosae; steroids; phytylester; tyrosinase inhibition; vitiligo; hyperpigmentation;

D O I：

10.1080/14786410500196821

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

Trifolium balansae ( Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T. balansae. The structures of the isolates were determined by 1D and 2DNMR techniques and MS spectroscopy. Compounds 1 - 5 were tested for their enzyme tyrosinase activity. While compounds 1 and 5 did not show any inhibition against the enzyme tyrosinase, compounds 2, 3, and 4 exhibited potent inhibition against tyrosinase. Highly potent ( IC50 = 2.39 mu M) inhibition was found by compound 2, when compared with the standard tyrosinase inhibitors Kojic acid and L-mimosine.

引用

页码：665 / 670

页数：6

共 15 条

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