Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells

被引：86

作者：

Zhang, L

Zhao, BY

Yew, DT

Kusiak, JW

Roth, GS

机构：

[1] NIA,MOL PHYSIOL & GENET SECT,CELLULAR & MOL BIOL LAB,NIH,BALTIMORE,MD 21224

[2] NIA,MOL NEUROBIOL UNIT,BIOL CHEM LAB,GERONTOL RES CTR,NIH,BALTIMORE,MD 21224

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 235卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The processing of Alzheimer's amyloid precursor protein was studied by Western blotting during H2O2 induced apoptosis in cultures of human neuroblastoma cells. A new 5.5 kDa fragment putatively containing intact A beta was detected and found to be highly associated with apoptosis. The results suggest a possible vicious cycle involving H2O2, A beta and apoptosis which may contribute to the neuronal death mechanism in Alzheimer's Disease. (C) 1997 Academic Press.

引用

页码：845 / 848

页数：4

共 29 条

[1]

ANDERSON AJ, 1995, J NEUROCHEM, V65, P1487

[2] VITAMIN-E PROTECTS NERVE-CELLS FROM AMYLOID BETA-PROTEIN TOXICITY [J].