General and efficient synthetic approach to novel tricyclic spiroketones

被引：2

作者：

Chu, Guo-Hua ^{[1
]}

Le Bourdonnec, Bertrand ^{[1
]}

Gu, Minghua ^{[1
]}

Saeui, Christopher T. ^{[1
]}

Dolle, Roland E. ^{[1
]}

机构：

[1] Adolor Corp, Dept Chem, Exton, PA 19341 USA

来源：

TETRAHEDRON | 2009年 / 65卷 / 27期

关键词：

RECEPTOR ANTAGONISTS; DISCOVERY; AGONISTS; POTENT;

D O I：

10.1016/j.tet.2009.04.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5161 / 5167

页数：7

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