Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats

被引:29
作者
Al-Howiriny, Tawfeq [2 ]
Alsheikh, Abdulmalik [3 ]
Alqasoumi, Saleh [1 ,2 ]
Al-Yahya, Mohammed [2 ]
ElTahir, Kamal [1 ]
Rafatullah, Syed [1 ]
机构
[1] King Saud Univ, Coll Pharm, MAPPRC, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
[3] King Saud Univ, Dept Pathol 32, King Khalid Univ Hosp, Riyadh 11461, Saudi Arabia
来源
AMERICAN JOURNAL OF CHINESE MEDICINE | 2009年 / 37卷 / 03期
关键词
Marjoram; Origanum majorana; Antiulcer; Antisecretory; Antioxidant; ENDOGENOUS SULFHYDRYLS; DUODENAL ANTIULCER; RESTRAINT STRESS; ULCER MODELS; ALBINO-RATS; BLOOD-FLOW; PREVENTION; LESIONS; CYTOPROTECTION; PATHOGENESIS;
D O I
10.1142/S0192415X0900703X
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
'Marjoram,' Origanum majorana L., a culinary aromatic medicinal herb is known to possess various therapeutic properties. We evaluated the antiulcerogenic activity of the ethanol extract in hypothermic restraint stress-, indomethacin-, necrotizing agents- (80% ethanol, 25% NaCl and 0.2 M NaOH) induced ulcers and basal gastric acid secretion using pylorus ligated Shay rat-model. Marjoram at doses of 250 and 500 mg/kg of body weight, significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract replenished the ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryls (NP-SH) contents and significantly lowered the increase in the concentration of malondialdehyde (MDA). Ulcer preventing potential was further confirmed by histopathological assessment. An acute toxicity test showed a large margin of safety of the extract in mice. The phytochemical screening of aerial parts of marjoram revealed the presence of volatile oil, flavonoids, tannins, sterols and/or triterpenes.
引用
收藏
页码:531 / 545
页数:15
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