Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats

被引:91
作者
Al-Rehaily, AJ
Al-Howiriny, TA
Al-Sohaibani, MO
Rafatullah, S
机构
[1] King Saud Univ, Coll Pharm, Med Aromat & Poisonous Plants Res Ctr, Riyadh 11451, Saudi Arabia
[2] King Khalid Univ Hosp, Dept Pathol, Coll Med, Riyadh 11472, Saudi Arabia
关键词
Amla; Emblica officinalis Gaertn; Euphorbiaceae; gastroprotection; traditional medicine;
D O I
10.1078/09447110260573146
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
An ethanol extract of 'Amla' Emblica officinalis Gaertn. was examined for its antisecretory and antiulcer activities employing different experimental models in rats, including pylorus ligation Shay rats, indomethacin, hypothermic restraint stress-induced gastric ulcer and necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl). Oral administration of Amla extract at doses 250 mg/kg and 500 mg/kg significantly inhibited the development of gastric lesions in all test models used. It also caused significant decrease of the pyloric-ligation induced basal gastric secretion, titratable acidity and gastric mucosal injury. Besides, Amla extract offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. Histopathological analyses are in good agreement with pharmacological and biochemical findings. The results indicate that Amla extract possesses antisecretory, antiulcer, and cytoprotective properties.
引用
收藏
页码:515 / 522
页数:8
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