RETRACTED: XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors (Retracted article. See vol. 111, pg. 12270, 2014)

被引:220
作者
Schlaberg, Robert [1 ]
Choe, Daniel J. [2 ]
Brown, Kristy R. [1 ]
Thaker, Harshwardhan M. [2 ]
Singh, Ila R. [1 ,2 ]
机构
[1] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA
[2] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA
关键词
Gleason; immunohistochemistry; retrovirus; RNaseL; xenotropic; VIRUS; STATISTICS; MORTALITY;
D O I
10.1073/pnas.0906922106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Xenotropic murine leukemia virus-related virus (XMRV) was recently discovered in human prostate cancers and is the first gammaretrovirus known to infect humans. While gammaretroviruses have wellcharacterized oncogenic effects in animals, they have not been shown to cause human cancers. We provide experimental evidence that XMRV is indeed a gammaretrovirus with protein composition and particle ultrastructure highly similar to Moloney murine leukemia virus (MoMLV), another gammaretrovirus. We analyzed 334 consecutive prostate resection specimens, using a quantitative PCR assay and immunohistochemistry (IHC) with an anti-XMRV specific antiserum. We found XMRV DNA in 6% and XMRV protein expression in 23% of prostate cancers. XMRV proteins were expressed primarily in malignant epithelial cells, suggesting that retroviral infection may be directly linked to tumorigenesis. XMRV infection was associated with prostate cancer, especially higher-grade cancers. We found XMRV infection to be independent of a common polymorphism in the RNASEL gene, unlike results previously reported. This finding increases the population at risk for XMRV infection from only those homozygous for the RNASEL variant to all individuals. Our observations provide evidence for an association of XMRV with malignant cells and with more aggressive tumors.
引用
收藏
页码:16351 / 16356
页数:6
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