A practical synthesis of optically active (R)-2-propyloctanoic acid:: Therapeutic agent for Alzheimer's disease

被引：67

作者：

Hasegawa, T ^{[1
]}

Yamamoto, H ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2000年 / 73卷 / 02期

关键词：

D O I：

10.1246/bcsj.73.423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(R)-2-Propyloctanoic acid has been developed as a novel therapeutic agent for Alzheimer's disease. A large-scale synthesis of this candidate was achieved by using Oppolzer's camphorsultam as a chiral auxiliary under improved conditions. It was essential for the successful synthesis of this compound to utilize a new removal method for the chiral source with a combination of tetrabutylammonium hydroxide and hydrogen peroxide. The present process afforded the desired product in high yield with high optical purity.

引用

页码：423 / 428

页数：6

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