Anti-anaerobic activity of AZD2563, a new oxazolidinone, compared with eight other agents

被引：14

作者：

Ednie, LM

Jacobs, MR

Appelbaum, PC

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 01期

关键词：

D O I：

10.1093/jac/dkf088

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The anti-anaerobic activity of AZD2563, a new oxazolidinone, was compared with that of eight other agents against 201 Gram-positive and 99 Gram-negative anaerobes. MIC50 and MIC90 values (mg/L) for the 201 Gram-positive organisms were as follows: AZD2563, 1.0/4.0; linezolid, 1.0/4.0; quinupristin/dalfopristin, 0.5/1.0; amoxicillin, 0.25/1.0; clindamycin, 0.25/8.0; metronidazole, 0.5/>16.0; vancomycin, 0.5/2.0; teicoplanin, 0.125/0.25; and meropenem, 0.06/1.0. AZD2563, linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin were mainly active against Gram-positive anaerobes, with no useful activity against Gram-negative anaerobes.

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页码：101 / 105

页数：5

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