Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers

被引:90
作者
Grobler, J [1 ]
Gray, CM
Rademeyer, C
Seoighe, C
Ramjee, G
Karim, SA
Morris, L
Williamson, C
机构
[1] Univ Cape Town, Inst Infect Dis & Mol Med, Div Med Virol, Observatory, South Africa
[2] S African Natl Bioinformat Inst, Cape Town, South Africa
[3] Natl Inst Communicable Dis, Johannesburg, South Africa
[4] Univ Natal, MRC, ZA-4001 Durban, South Africa
[5] Univ Natal, Ctr AIDS Programme Res S Africa, ZA-4001 Durban, South Africa
关键词
D O I
10.1086/423940
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This longitudinal study aimed to determine the incidence and pathogenic implications of dual human immunodeficiency virus type 1 (HIV-1) infection in a cohort of female sex workers. Blood samples from 31 recently infected women were screened by use of a heteroduplex mobility assay and sequencing. The median viral load set point was 5404 copies/mL (n=22), which was measured by use of the bDNA assay. Within 3 months of infection, 19% (6/31) of the women were dually infected with 2 distinct HIV-1 subtype C viruses. No evidence of superinfection was detected over the course of 24 months of follow-up, indicating that the risk of dual infection is highest around the time of the initial infection. There was a significant association between dual infection and elevated viral load set point.
引用
收藏
页码:1355 / 1359
页数:5
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