Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

被引：35

作者：

Kurihara, N

Reddy, SV

Araki, N

Ishizuka, S

Ozono, K

Cornish, J

Cundy, T

Singer, FR

Roodman, GD

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med Hematol & Oncol, Pittsburgh, PA 15261 USA

[2] Kumamoto Univ, Sch Med, Dept Tumor Genet & Biol, Kumamoto 860, Japan

[3] Teijin Inst Biomed Res, Tokyo, Japan

[4] Osaka Univ, Sch Med, Dept Pediat, Suita, Osaka 565, Japan

[5] Univ Auckland, Dept Med, Auckland 1, New Zealand

[6] John Wayne Canc Ctr, Dept Endocrinol, Santa Monica, CA USA

[7] Vet Affairs Med Ctr, Pittsburgh, PA USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 07期

关键词：

TAF(II)-17; Paget's disease; 1,25-dihydroxyvitamin D-3; osteoclast formation; bone marrow cultures;

D O I：

10.1359/JBMR.040312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In contrast to normal OCL precursors, pagetic OCL precursors express MVNP and form OCL at physiologic concentrations of 1,25(OH)(2)D-3, as do normal OCL precursors transfected with the MVNP gene. Using a GST-VDR chimeric protein, we identified TAF(II)-17 as VDR binding protein expressed by pagetic OCL precursors and MVNP transduced normal OCL precursors. TAF(II)-17 was in part responsible for the increased 1,25(OH)(2)D-3 responsivity of pagetic OCL precursors.

引用

收藏

页码：1154 / 1164

页数：11

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