Chemotherapy as initial treatment in gliomatosis cerebri - Results with temozolomide

被引：47

作者：

Levin, N

Gomori, JM

Siegal, T

机构：

[1] Hadassah Hebrew Univ Hosp, Leslie & Michael Gaffin Ctr Neurooncol, Jerusalem, Israel

[2] Hadassah Hebrew Univ Hosp, Neuroimaging Unit, Jerusalem, Israel

来源：

NEUROLOGY | 2004年 / 63卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000130249.41341.58

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The optimal therapy for gliomatosis cerebri is unclear, and the rate of response to chemotherapy is not known. Eleven radiotherapy-naive patients received a median number of 10 treatment cycles of temozolomide. An objective response was documented in 45%, and the median time to tumor progression was 13 months with a progression-free survival of 55% at 12 months. These results indicate that radiotherapy to extensive brain regions can be deferred until progressive disease is observed.

引用

页码：354 / 356

页数：3

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