Genotypic diversity and antibiotic susceptibility of Acinetobacter baumannii isolates in a Bulgarian hospital

被引：21

作者：

Dobrewski, R.

Savov, E.

Bernards, A. T.

van den Barselaar, M.

Nordmann, P.

van den Broek, P. J.

Dijkshoorn, L.

机构：

[1] Leiden Univ, Med Ctr, Ctr Infect Dis, Dept Infect Dis, NL-2300 RC Leiden, Netherlands

[2] Mil Med Acad, Dept Clin Microbiol, Sofia, Bulgaria

[3] Leiden Univ, Med Ctr, Dept Med Microbiol, NL-2300 RC Leiden, Netherlands

[4] Hop Bicetre, Dept Bacteriol Virol, Le Kremlin Bicetre, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 11期

关键词：

Acinetobacter baumannii; AFLP typing; antibiotic susceptibility; Bulgaria; genotypes; nosocomal infection;

D O I：

10.1111/j.1469-0691.2006.01530.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A set of 18 Acinetobacter baumannii isolates, collected prospectively in a Bulgarian hospital during episodes of increased A. baumannii occurrence during 2000-2002, was investigated for genotypic diversity and antibiotic susceptibility. Four genotypes were identified by amplified fragment length polymorphism genomic fingerprinting, one of which (type 1) accounted for 13 isolates, indicating that a specific strain was predominant. The single isolate allocated to type 2 was identified to European clone I. All isolates were resistant to multiple antibiotics, but most retained susceptibility to tobramycin and colistin, and all except one were susceptible to imipenem.

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收藏

页码：1135 / 1137

页数：3

相关论文

共 10 条

[1] Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods [J].

Dijkshoorn, L ;

Aucken, H ;

GernerSmidt, P ;

Janssen, P ;

Kaufmann, ME ;

Garaizar, J ;

Ursing, J ;

Pitt, TL .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (06) :1519-1525

[2] Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species [J].

Dijkshoorn, L ;

van Harsselaar, B ;

Tjernberg, I ;

Bouvet, PJM ;

Vaneechoutte, M .

SYSTEMATIC AND APPLIED MICROBIOLOGY, 1998, 21 (01) :33-39

[3] Investigation of an outbreak of multidrug-resistant Acinetobacter baumannii in trauma intensive care unit [J].

El Shafie, SS ;

Alishaq, M ;

Garcia, ML .

JOURNAL OF HOSPITAL INFECTION, 2004, 56 (02) :101-105

[4] Long-term predominance of two pan-European clones among multi-resistant Acinetobacter baumannii strains in the Czech Republic [J].

Nemec, A ;

Dijkshoorn, L ;

van der Reijden, TJK .

JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 53 (02) :147-153

[5] Acinetobacter ursingii sp nov and Acinetobacter schindleri sp nov., isolated from human clinical specimens [J].

Nemec, A ;

De Baere, T ;

Tjernberg, I ;

Vaneechoutte, M ;

van der Reijden, TJK ;

Dijkshoorn, L .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2001, 51 :1891-1899

[6] Outbreak of extended-spectrum β-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital [J].

Poirel, L ;

Menuteau, O ;

Agoli, N ;

Cattoen, C ;

Nordmann, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (08) :3542-3547

[7] In vitro investigation of the susceptibility of Acintetobacter baumannii strains isolated from clinical specimens to ampicillin/sulbactam alone and in combination with amikacin [J].

Savov, E ;

Chankova, D ;

Vatcheva, R ;

Dinev, N .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 20 (05) :390-392

[8] Widespread detection of PER-1-type extended-spectrum beta-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey: a nationwide multicenter study [J].

Vahaboglu, H ;

Ozturk, R ;

Aygun, G ;

Coskunkan, F ;

Yaman, A ;

Kaygusuz, A ;

Leblebicioglu, H ;

Balik, I ;

Aydin, K ;

Otkun, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2265-2269

[9] Identification of a new geographically widespread multiresistant Acinetobacter baumannii clone from European hospitals [J].

van Dessel, H ;

Dijkshoorn, L ;

van der Reijden, T ;

Bakker, N ;

Paauw, A ;

van den Broek, P ;

Verhoef, J ;

Brisse, S .

RESEARCH IN MICROBIOLOGY, 2004, 155 (02) :105-112

[10] Outbreak of nosocomial meningitis caused by Acinetobacter baumannii in neurosurgical patients [J].

Wroblewska, MM ;

Dijkshoorn, L ;

Marchel, H ;

van den Barselaar, M ;

Swoboda-Kopec, E ;

van den Broek, PJ ;

Luczak, M .

JOURNAL OF HOSPITAL INFECTION, 2004, 57 (04) :300-307