Biocompatibility and antibacterial activity studies of polyamidoamine (PAMAM) dendron, side chain dendritic oligourethane (SCDOU)

被引：11

作者：

Ghosh, S ^{[1
]}

Banthia, AK ^{[1
]}

机构：

[1] Indian Inst Technol, Ctr Mat Sci, Kharagpur 721302, W Bengal, India

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2004年 / 71A卷 / 01期

关键词：

polyamidoamine (PAMAM); side chain dendritic oligourethane (SCDOU); cytotoxicity; antibacterial;

D O I：

10.1002/jbm.a.30121

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Cytotoxicity of both polyamidoamine dendritic diol (PAMAM) and side chain dendritic oligourethane (SCDOU) was studied through interaction with mammalian fibroblast cells (L929). Cell metabolic activity in the presence of dendritic polymers was measured using an MTT assay exhibiting significant cell viability. Additionally, the antibacterial activity of PAMAM dendron, SCDOU, as well as their silver-doped structures was studied against Escherichia coli bacteria. The results showed that the silver-doped structures attain high antibacterial activity. Formation of silver-doped dendritic polymers was investigated from the UV-visible plasmon absorption band of silver particles. (C) 2004 Wiley Periodicals, Inc.

引用

页码：1 / 5

页数：5

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