Microfluidic chip: Next-generation platform for systems biology

被引：72

作者：

Feng, Xiaojun ^{[1
]}

Du, Wei ^{[1
]}

Luo, Qingming ^{[1
]}

Liu, Bi-Feng ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Key Lab Biomed Photon MOE,Coll Life Sci & Technol, Div Biomed Photon,Dept Syst Biol,Wuhan Natl Lab O, Wuhan 430074, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2009年 / 650卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Microfluidic chip; Systems biology; Omics; Cell; C; elegans; CAPILLARY ARRAY ELECTROPHORESIS; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; NATURAL PH GRADIENTS; PATCH-CLAMP ARRAY; HIGH-SPEED; MICROFABRICATED DEVICE; MASS-SPECTROMETRY; CHEMICAL-ANALYSIS; CELL-SEPARATION;

D O I：

10.1016/j.aca.2009.04.051

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Systems biology advocates the understanding of biology at the systems-level, which requires massive information of correlations among individual components in complex biological systems. Such comprehensive investigation entails the use of high-throughput analytical tools. Microfluidic technology holds high promise to facilitate the progress of biology by enabling miniaturization and upgrading of current biological research tools due to its advantages such as low sample consumption, reduced analysis time, high-throughput and compatible sizes with most biological samples. In this article. we documented the recent applications of microfluidic chips in biological researches at the molecular level, cellular level and organism level, serving the purpose for systems-level understanding of biology. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：83 / 97

页数：15

共 211 条

[41] Immunomagnetic T cell capture from blood for PCR analysis using microfluidic systems [J].