Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives

被引：9

作者：

Cointeaux, L

Berrien, JF

Peyrou, V

Provot, O

Ciceron, L

Danis, M

Robert, A

Meunier, B

Mayrargue, J

机构：

[1] BioCIS, UPRES A 8076, Lab Synth & Concept Mol Interet Therapeut, Fac Pharm, F-92296 Chatenay Malabry, France

[2] Grp Hosp Pitie Salpetriere, INSERM, U511, F-75013 Paris, France

[3] CNRS, Lab Chim Coordinat, F-31077 Toulouse 4, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(02)00837-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn-II-TPP. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：75 / 77

页数：3