Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes

被引：144

作者：

Campbell-Verduyn, Lachlan S. ^{[2
]}

Mirfeizi, Leila ^{[1
]}

Dierckx, Rudi A. ^{[1
]}

Elsinga, Philip H. ^{[1
]}

Feringa, Ben L. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands

[2] Univ Groningen, Stratingh Inst Chem, Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 16期

关键词：

1,3-DIPOLAR CYCLOADDITION; CLICK CHEMISTRY; LIGANDS; COPPER(I); CATALYSTS;

D O I：

10.1039/b822994e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monodentate phosphoramidite ligands are used to accelerate the copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(I) and Cu(II) salts both function as the copper source in aqueous solution to provide excellent yields.

引用

页码：2139 / 2141

页数：3

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