Genetic dissection of antigen receptor induced-NF-κB activation

被引：38

作者：

Li, ZW

Rickert, RC

Karin, M

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[2] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 6-7期

关键词：

NF-kappa B; IKK; TLR; TCR; BCR;

D O I：

10.1016/j.molimm.2004.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NF-kappaB is a master transcription factor in the immune system. It regulates various aspects of immune cell development, homeostasis, survival and function. It is in these contexts that the signaling pathways leading to NF-kappaB activation are best understood. This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis of mice lacking specific signaling intermediates. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：701 / 714

页数：14

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