Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

被引：91

作者：

Pan, Chen-wei ^{[1
,2
]}

Pan, Zhen-zhen ^{[3
]}

Hu, Jian-jian ^{[2
,4
]}

Chen, Wei-lai ^{[5
]}

Zhou, Guang-yao ^{[1
,2
]}

Lin, Wei ^{[1
,2
]}

Jin, Ling-xiang ^{[1
,2
]}

Xu, Chang-long ^{[2
,6
]}

机构：

[1] Wenzhou Med Univ, Dept Infect Dis, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Dept Infect Dis, Affiliated Hosp 1, Wenzhou 325000, Peoples R China

[4] Wenzhou Med Univ, Intens Care Unit, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

[5] Wenzhou Peoples Hosp, Dept Neurol, Wenzhou 325027, Peoples R China

[6] Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 770卷

关键词：

Mangiferin; LPS; Nrf2; NLRP3; NF-KAPPA-B; FULMINANT HEPATIC-FAILURE; NECROSIS-FACTOR-ALPHA; L. EXTRACT VIMANG; OXIDATIVE STRESS; AST/ALT RATIO; DISEASE; MECHANISMS; MICE; TNF;

D O I：

10.1016/j.ejphar.2015.12.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Mangiferin, a glucosylxanthone from Mangifera indica, has been reported to have anti-inflammatory effects. However, the protective effects and mechanisms of mangiferin on liver injury remain unclear. This study aimed to determine the protective effects and mechanisms of mangiferin on lipopolysaccharide (LPS) and D-galactosamine (D-GaIN)-induced acute liver injury. Mangiferin was given 1 h after LPS and D-GaIN treatment. The results showed that mangiferin inhibited the levels of serum ALT, AST, IL-1 beta, TNF-alpha, MCP-1, and RANTES, as well as hepatic malondialdehyde (MDA) and ROS levels. Moreover, mangiferin significantly inhibited IL-1 beta and TNIF-alpha production in LPS-stimulated primary hepatocytes. Mangiferin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner. Furthermore, mangiferin inhibited LPS/D-GaIN-induced hepatic NLRP3, ASC, caspase-1, IL-1 beta and TNIF-alpha expression. In conclusion, mangiferin protected against LPS/GaIN-induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. (C) 2015 Elsevier BY. All rights reserved.

引用

页码：85 / 91

页数：7

共 35 条

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