IFITMs Restrict the Replication of Multiple Pathogenic Viruses

被引：172

作者：

Perreira, Jill M. ^{[1
]}

Chin, Christopher R. ^{[1
]}

Feeley, Eric M. ^{[1
]}

Brass, Abraham L. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Microbiol & Physiol Syst MaPS Dept, Worcester, MA 01655 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2013年 / 425卷 / 24期

基金：

美国国家卫生研究院;

关键词：

interferon effector genes; PAROXYSMAL KINESIGENIC DYSKINESIA; HEPATITIS-C VIRUS; IMPERFECTA TYPE-V; INFLUENZA-A VIRUS; WEST NILE VIRUS; CELL ENTRY; HEMORRHAGIC-FEVER; PRRT2; GENE; TRANSMEMBRANE PROTEINS; PHENOTYPIC VARIABILITY;

D O I：

10.1016/j.jmb.2013.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interferon-inducible transnnembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：4937 / 4955

页数：19

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